Extended Data Fig. 3: Increased tissue-scale forces result in increased fibrosis around implants in mice, independently of implant chemistry or mechanical properties. | Nature Biomedical Engineering

Extended Data Fig. 3: Increased tissue-scale forces result in increased fibrosis around implants in mice, independently of implant chemistry or mechanical properties.

From: Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

Extended Data Fig. 3

(a,b) Trichrome staining and Herovici staining of FBR capsules formed around standard murine implants with low stiffness, standard implants with high stiffness, and MSIs reveals that MSI-model produces a more robust scar tissue, with increased collagen and mature collagen. Representative images are shown from similar images across n = 5 independent capsules per group. Scale bar = 500 μm.

Back to article page