Extended Data Fig. 7: Zip2R augments the antitumor activity of EphA2-CAR in the A673 model. | Nature Biomedical Engineering

Extended Data Fig. 7: Zip2R augments the antitumor activity of EphA2-CAR in the A673 model.

From: Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling

Extended Data Fig. 7

a, Experimental scheme of s.c. A673 model; mice received a single i.v. dose of 1x106 CAR T cells on day 7 post tumor cell injection. b, Tumor volume of mice treated with indicated constructs (N = 4; donor 1). c, Kaplan-Meier survival curve (*p = 0.0438, log-rank test). d, Tumor volume of mice treated with indicated constructs (N = 5; donor 2). e, Tumor volume following rechallenge (dashed line) with A673 WT cells on the contralateral flank (N = 5 (CAR), N = 4 (CAR.Zip2R); tumor rejection: CAR: 0/5; CAR.Zip2R: 2/4). f, Kaplan Meier survival following rechallenge.

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