Extended Data Fig. 2: Lineage tracing of diverse airway progenitors after bleomycin injury.
(a, b) p63 Lin+ cells also expanded into the alveoli after bleomycin but did not contribute significantly to KRT5 + basal cells in the alveoli. (n = 3 animals). Data are expressed as mean ± SD. (c, d) Comparison of p63 Lin+ and Sox2 Lin+ cells that expand into the alveoli after bleomycin injury. (n = 3 for p63 Lin, n = 6 for Sox2 Lin; each data point represents one animal; one-tailed unpaired Student’s t-test). Data are expressed as mean ± SD. (e, f) Contribution of Scgb1a1 Lin+ cells to the various epithelial lineages in the alveoli after bleomycin injury. (n = 3 per group; each data point represents one animal). Data are expressed as mean ± SD. AW = airway. Scale bars, 100 μm.
