Extended Data Fig. 8: GATA2 drives LEN-induced megakaryocytic differentiation.
e, MDS-L transduced with lentivirus encoding shRNAs targeting GATA2 expression show reduced GATA2 protein levels by Western blot compared to control shRNA-expressing cells. GAPDH is shown as loading control. (n = 3 independent experiments). f, Human ITGA2B (CD41) promoter activation by GATA2 is inhibited by co-expression of IKZF1 in HEK293T cells. (n = 6 independent experiments). Statistical analysis was performed using two-sided Student’s t-test. Data is presented as mean ± s.d. Source data are available online.
