Extended Data Fig. 1: Whole genome and expression analysis in del(5q) MDS at relapse. | Nature Cell Biology

Extended Data Fig. 1: Whole genome and expression analysis in del(5q) MDS at relapse.

From: Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome

Extended Data Fig. 1

a, Copy number analysis of WGS data showing that deletion of the 5q CDR is conserved at relapse in our cohort of del(5q) MDS patients. The x-axis represents the length of chromosome 5 and the y-axis shows the copy number ratio for each chromosomal ___location. Numbers in red represent mean log2 ratio of chromosome 5q copy number relative to normal. b, Variant allele frequency (VAF) of protein-coding genes in the FoundationOne heme panel at relapse for each patient. c, Relative mRNA expression change of TP53 in this cohort of del(5q) MDS patient marrows at relapse assessed by RT-qPCR. Data is shown as log2fold expression at relapse relative to diagnosis. d,e, Copy number analysis inferred from WGS data for chromosome 17p (d) and chromosome 21 (e). The x-axis represents the length of chromosome and the y-axis shows the copy number ratio for each chromosomal ___location. RUNX1 and TP53 chromosomal ___location is marked. The numbers represent mean log ratio of the corresponding gene copy number variation relative to normal.

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