Fig. 7: SARS-CoV-2 infection causes DNA damage in hACE2-mouse lungs. | Nature Cell Biology

Fig. 7: SARS-CoV-2 infection causes DNA damage in hACE2-mouse lungs.

From: SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

Fig. 7

a, IHC images of lungs from SARS-CoV-2-infected hACE2-mice or mock-infected (PBS) wild-type mice that were stained for the indicated markers at 6 days following intranasal administration; the presence of the virus was assessed by staining for SARS-CoV-2 N or by probing the viral genome through RNA ISH; nuclei were stained with haematoxylin (light blue). Scale bar, 50 μm. b, Quantification of the percentage of cells positive for the indicated markers as shown in a. Values are the mean ± s.e.m.; at least three mice were studied for each condition; the precise number is indicated below each histogram. Source numerical data are available in source data.

Source data

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