Extended Data Fig. 9: LPCAT1 promotes tumour development by ferroptosis evasion.
From: LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
a, IB analysis of LPCAT1 expression in the indicated cancer cells. GAPDH served as a loading control. Protein quantified against controls, set as 1.0. b, Viability analysis of the indicated cells treated with RSL3 for 24 h. c, Heatmaps showing the knockdown efficiency of LPCAT1 in the indicated cells. d, Viability analysis of the indicated cells treated with RSL3 for 24 h. e, Viability analysis of the indicated cells treated with IKE (2 μM) or IKE (2 μM) plus Fer-1 (4 μM) for 24 h. f–h, Upper: IB analysis of LPCAT1 expression in the indicated tumour cells. GAPDH served as a loading control. Lower: Tumour growth curves of the indicated xenografts. n = 5 animals per group. Data are presented as mean ± SD, n = 3 biologically independent samples in a-h. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s test in b, e-h. NS, not significant.
