Extended Data Fig. 9: The definition of the trajectories of myogenesis.
From: A single-cell atlas of chromatin accessibility in mouse organogenesis
a, UMAP visualization showing the enrichment of 14 myogenesis-related gene modules. A full list of genes in the module is from Cao, et al.8. b, Pseudotime representation of four potentially differential paths of myocytes. The line represents a double-spline fitted trajectory across pseudotime. c, Luciferase activities of 18 tested ACRs in C2C12 myoblast and C2C12 induced myotubes. The y-axis represents the fold change of normalized luciferase activity (Firefly/Renilla) over control. Each column represents the mean ± SD of three independent experiments (Paired two-sided Student’s t-test). *P < 0.05, **P < 0.01. The exact P values of basic vector and ACR1-ACR18 are 1.00, 0.00965, 0.00895, 0.0116, 0.195, 0.0155, 0.0504, 0.221, 0.0181, 0.0839, 0.868, 0.0105, 0.100, 0.0106, 0.983, 0.298, 0.0602, 0.00600, 0.00749. Source numerical data are provided as source data.
