Fig. 5: Coupling of rECs and remodelling bone.
From: Specialized post-arterial capillaries facilitate adult bone remodelling
a,b, High-resolution confocal images showing EMCN+VEGFR3− rECs (arrowheads) around TB in relation to RUNX2+ osteoprogenitors (green) (a) and ATP6V1B1/B2+ osteoclasts (green) (b). c,d, Maximum-intensity projection showing Sp7-mCherry+ osteoblasts (yellow) and ATP6V1B1/B2+ osteoclasts (green) in in relation to EMCN+VEGFR3− rECs around 6-week-old femoral TB (c). Single xy plane (d). Green arrowheads mark rECs near osteoclasts and yellow arrowheads near osteoblasts. e,f, Distribution of EMCN+VEGFR3− type R vessels in relation to Sp7-mCherry+ osteoblasts (yellow arrowheads) and ATP6V1B1/B2+ osteoclasts (green arrowheads) around 6-week-old and 12-week-old TB (e). Isolated xy plane (f). g, Confocal images showing VEGFR3−VEGFR2+ ECs (white arrowheads) around TB in young and aged patient samples. VEGFR3 (yellow), VEGFR2 (red) and nuclei (DAPI, blue). DAPI, 4,6-diamidino-2-phenylindole.
