Extended Data Fig. 3: Flow diagram illustrating the modules and procedure of simulation. | Nature Ecology & Evolution

Extended Data Fig. 3: Flow diagram illustrating the modules and procedure of simulation.

From: Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

Extended Data Fig. 3

. Each simulation starts from a single tumour voxel that harbours a VHL mutation and 3p loss and runs until the tumour grows to at least 1 million voxels. During a model iteration, events including death, proliferation, acquisition of drivers, and necrosis are evaluated and simulated.

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