Table 1 MVMR results for poverty and CA on mental illness

From: Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization

MVMR

No. of SNPs

IVW β (95% CI)

IVW P

Outcome: ADHD

203

  

Exposure 1: PF

 

0.232 (0.169, 0.295)

7.28 × 10−13

Exposure 2: CA

 

−0.477 (−0.612, −0.342)

4.31 × 10−12

Outcome: AN

205

  

Exposure 1: PF

 

−0.109 (−0.183, −0.035)

0.004

Exposure 2: CA

 

0.149 (−0.008, 0.306)

0.062

Outcome: ANX

207

  

Exposure 1: PF

 

0.114 (0.007, 0.221)

0.036

Exposure 2: CA

 

−0.344 (−0.571, −0.117)

0.003

Outcome: ASD

208

  

Exposure 1: PF

 

0.022 (−0.054, 0.099)

0.564

Exposure 2: CA

 

0.217 (0.054, 0.379)

0.009

Outcome: BD

208

  

Exposure 1: PF

 

0.020 (−0.044, 0.085)

0.538

Exposure 2: CA

 

0.006 (−0.132, 0.144)

0.931

Outcome: MDD

208

  

Exposure 1: PF

 

0.076 (0.030, 0.123)

0.001

Exposure 2: CA

 

−0.091 (−0.190, 0.008)

0.071

Outcome: OCD

208

  

Exposure 1: PF

 

−0.202 (−0.340, −0.0.064)

0.004

Exposure 2: CA

 

0.320 (0.024, 0.615)

0.034

Outcome: PTSD

208

  

Exposure 1: PF

 

0.111 (0.048, 0.173)

4.90 × 10−4

Exposure 2: CA

 

−0.160 (−0.294, −0.027)

0.019

Outcome: SZ

208

  

Exposure 1: PF

 

0.092 (0.018, 0.167)

0.015

Exposure 2: CA

 

−0.297 (−0.457, −0.136)

2.94 × 10−4

  1. ‘IVW’ indicates multivariable MR via the IVW method (random effects); the β effect estimates are log-odds.
  2. Poverty is a latent variable built using HI as a unit identification, so that an increase in the indicator’s load stands for increased income; the regression coefficients have therefore been reversed to facilitate interpretation of the effect of poverty. All statistical tests are two-sided. The P values were not adjusted for multiple testing; therefore, P < 0.05 was considered significant (and is reported in bold).
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