Extended Data Fig. 3: Association of genetic burden for recessive disease with educational attainment, fluid intelligence score, and log-transformed number of ICD-10 diagnoses for different constraint scores.
From: Reproductive and cognitive phenotypes in carriers of recessive pathogenic variants
Associations of genetic burden with educational attainment (measured in years of education), fluid intelligence score and log-transformed number of ICD-10 diagnoses for PLPs in all recessive (purple) genes and singleton LoFs in non-recessive highly constrained (green) genes. Colored lines indicate effect sizes (ES; estimated regression coefficients) with 99% confidence intervals. The dashed gray line indicates ES = 0, which serves as the reference point. Statistically significant deviations from ES = 0 are tested using a two-sided Wald test. The corresponding p-values are displayed in the figure and adjusted for multiple comparisons using the Bonferroni correction. Statistically significant associations are marked with an asterisk. The results are for three different s-het scores: Weghorn (a), Cassa (b) and pLI (c).
