Fig. 2: P-selectin-targeted nanoparticles preferentially target SHH-MB tumours following low-dose irradiation. | Nature Materials

Fig. 2: P-selectin-targeted nanoparticles preferentially target SHH-MB tumours following low-dose irradiation.

From: P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Fig. 2

a, Atomic force micrograph of FiVis nanoparticles. b, DLS data showing average size of FiVis nanoparticles (as quantified by intensity distribution). PDI, polydispersity index; d, diameter. c, Zeta potential measurements of FiVis nanoparticles. d, Representative near-infrared images (dorsal view) of brains from WT and SHH-MB mice administered FiVis nanoparticles. n = 3 mice per group in each of two independent experiments. e, Top, near-infrared fluorescence intensities of FiVis nanoparticles in tumour regions (cerebellum) and nontumour regions (forebrain) of WT, SHH-MB and P-selectin (SELP) null SHH-MB mice. Bottom, representative dorsal images of brains, demarcated by cerebellum and forebrain (yellow) for quantification. n = 3 mice per group; *P < 0.05, **P < 0.01, ***P < 0.001 (two-tailed t-test); NS, not significant. f, Liquid chromatography–tandem mass spectrometry quantification of vismodegib in cerebellar and forebrain tissue of mice treated with 0.25 Gy XRT and 10 mg kg–1 FiVis. n = 5 mice per group; *P < 0.05, P = .0424 (paired, two-tailed t-test). e,f, Data are means ± s.e.m.

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