Extended Data Fig. 6: Single-cell MALT1 fluorescent intensity and protein count.
a, Distribution of fluorescent intensity of HBL1 cells from six separate organoids for MALT1 after 48 h of culture in indicated conditions and subsequent 48 h of MI2 treatment. Total number of cells is indicated in red. Organoids without (left) and with CD40L-stromal cells (right) were respectively treated with 250 nM and 2000 nM MI2. b, Distribution of fluorescent intensity of ABC-DLBCL PDXs from six separate organoids for MALT1 after 48 h of culture in indicated conditions and subsequent 48 h of MI2 treatment. Organoids without and with CD40L-stromal cells were respectively treated with 2000 nM MI2. c, Protein expression of the six highest expressed proteins, from NanoString analysis in Fig. 4, in cells cultured in GFOGER-functionalized organoids and REDV-functionalized organoids with CD40L-stromal cells. Results indicate mean ± s.e.m. of two replicates, with each replicate including at least 60 organoids.
