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Lipid discovery for mRNA delivery guided by machine learning

Nature Materials volume 23, pages 880–881 (2024)Cite this article

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Combining machine learning with high-throughput synthesis expedites ionizable cationic lipid development for nanoparticle-based messenger RNA delivery.

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Fig. 1: Integrating machine learning with advanced combinatorial chemistry to accelerate ionizable cationic lipid development.

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Authors and Affiliations

  1. Laboratory of Chemical Biology, Department of Biomedical Engineering and the Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

    Roy van der Meel & Willem J. M. Mulder

  2. Department of Biomedical Engineering, Institute for Complex Molecular Systems and Eindhoven Artificial Intelligence Systems Institute, Eindhoven University of Technology, Eindhoven, The Netherlands

    Francesca Grisoni

  3. Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, Utrecht, The Netherlands

    Francesca Grisoni

  4. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

    Willem J. M. Mulder

Authors
  1. Roy van der Meel
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  2. Francesca Grisoni
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  3. Willem J. M. Mulder
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Correspondence to Roy van der Meel.

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The authors declare no competing interests.

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van der Meel, R., Grisoni, F. & Mulder, W.J.M. Lipid discovery for mRNA delivery guided by machine learning. Nat. Mater. 23, 880–881 (2024). https://doi.org/10.1038/s41563-024-01934-9

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