Extended Data Fig. 3: Schematic of how Ece1 modification (NCEP modifications or deletions) promotes ER stress and an unfolded protein response.
From: Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
Left: In Wt C. albicans cells, transcription of native ECE1 is followed by translation and folding of Ece1 in the ER, transport to the Golgi apparatus and sequential processing by Kex2 and Kex1 proteases, enabling candidalysin and NCEP secretion. Right: In NCEP mutants, the modified Ece1 structure promotes misfolding which triggers ER stress. Ece1 modifications hinder correct Kex2/1 processing leading to abolished or impaired secretion of candidalysin. The figures were drawn using pictures from Servier Medical Art by Servier, licensed under a Creative Commons Attribution 3.0 Unported License.
