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The role of DNA damage in diabetic complications

Mechanistic and clinical data indicate that DNA damage contributes to the pathogenesis and progression of diabetic complications. Thus, DNA damage and its signalling are entering the field of diabetology.

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Fig. 1: Causes and types of DNA damage in individuals with diabetes mellitus.

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Acknowledgements

We thank R. Kuner, P. Janscak and R. Pepperkok (members of LHI Munich, ALMF-EMBL Heidelberg and DZD e.V., respectively) for their support. The authors also thank Deutsche Forschungsgemeinschaft (DFG project number 548178547/Dr Varun Kumar) for funding support.

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Correspondence to Varun Kumar or Peter P. Nawroth.

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Kumar, V., Yildirim, A.Ö. & Nawroth, P.P. The role of DNA damage in diabetic complications. Nat Rev Endocrinol 20, 629–630 (2024). https://doi.org/10.1038/s41574-024-01038-z

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