Mechanistic and clinical data indicate that DNA damage contributes to the pathogenesis and progression of diabetic complications. Thus, DNA damage and its signalling are entering the field of diabetology.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
27,99 € / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
209,00 € per year
only 17,42 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout

References
Varun, K. et al. Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetes. EBioMedicine 90, 104516 (2023).
Schumacher, D. et al. Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes. Mol. Metab. 18, 143–152 (2018).
Kumar, V. et al. Compromised DNA repair is responsible for diabetes-associated fibrosis. EMBO J. 39, e103477 (2020).
Han, Z. et al. The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Res. 51, 2298–2318 (2023).
Reddy, M. A., Zhang, E. & Natarajan, R. Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia 58, 443–455 (2015).
van Vugt, M. A. Shutting down the power supply for DNA repair in cancer cells. J. Cell Biol. 216, 295–297 (2017).
Bhatt, S. et al. Preserved DNA damage checkpoint pathway protects against complications in long-standing type 1 diabetes. Cell Metab. 22, 239–252 (2015).
Al-Dabet, M. M. et al. Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression. Nat. Commun. 13, 5062 (2022).
Morgenstern, J. et al. Phosphorylation of T107 by CamKIIδ regulates the detoxification efficiency and proteomic integrity of glyoxalase 1. Cell Rep. 32, 108160 (2020).
Kumar, V. & Nawroth, P. P. Is the association between diabetes mellitus and pulmonary fibrosis real? Nat. Rev. Endocrinol. 17, 703–704 (2021).
Acknowledgements
We thank R. Kuner, P. Janscak and R. Pepperkok (members of LHI Munich, ALMF-EMBL Heidelberg and DZD e.V., respectively) for their support. The authors also thank Deutsche Forschungsgemeinschaft (DFG project number 548178547/Dr Varun Kumar) for funding support.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Supplementary information
Rights and permissions
About this article
Cite this article
Kumar, V., Yildirim, A.Ö. & Nawroth, P.P. The role of DNA damage in diabetic complications. Nat Rev Endocrinol 20, 629–630 (2024). https://doi.org/10.1038/s41574-024-01038-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41574-024-01038-z