Extended Data Fig. 7: Associations between probabilities of distant relapse ten years after locoregional relapse with clinico-pathological and molecular features of the primary tumour.

For each patient that had a locoregional recurrence, the ten-year probability of having a distant relapse or cancer-related death is plotted against different variables. A loess fit is overlaid to highlight the relationship between the probability and tumour size or time of relapse. Box plots were computed using the median of the observations (centre line). The first and third quartiles are shown as boxes, and the whiskers extend to the ±1.58 interquartile range divided by the square root of the sample size. Outliers are shown as dots. This analysis was done with the molecular dataset and the model was stratified by IntClust subtype (n = 257).