Extended Data Fig. 9: Distribution of the number of relapses by molecular subtype.

a, Times of distant recurrence for ER⁻ and ER⁺ patients (n = 605). Each dot represents a distant recurrence, coded by colour for different sites. b, Distribution of the number of distant relapses for different subtypes (n = 609), based on ER status (ER⁺ n = 422, ER⁻ n = 187), IHC ER/HER2 status (ER⁺/HER2⁻ n = 263, ER⁻/HER2⁻ n = 82, ER⁺/HER2⁺ n = 36, ER⁻/HER2⁺ n = 41), PAM50 subtype (normal n = 33, luminal A n = 101, luminal B n = 138, basal n = 79, HER2 n = 69) and IntClust subtype (IC1 n = 40, IC2 n = 25, IC3 n = 32, IC4ER⁺ n = 46, IC4ER⁻ n = 16, IC5 n = 72, IC6 n = 23, IC7 n = 24, IC8 n = 54, IC9 n = 38, IC10 n = 52). ER status was imputed on the basis of expression in four samples. These analyses were done with the recurrent-events cohort.