Extended Data Fig. 10: Cells preferentially expelled from the lymph nodes are marked by a distinct transcriptional profile.

a, Gene sets (canonical pathways; CP) enriched in differentially expressed genes (n = 336) between the T₁-enriched clade of cells and the remaining T₁ cells identified from the lineage trees in Fig. 4b and Extended Data Fig. 9a. A two-sided hypergeometric test was used to measure the enrichment of these genes in each gene set, followed by a Benjamini–Hochberg (BH) FDR procedure (cut-off of adjusted P < 0.2). b, Gene expression projections on lineage tree for TLR pathway genes from Fig. 4d for samples CLL04, CLL05 and CLL11, respectively. Scale bar represents RNA read counts scaled by maximal value. Expression value projection is performed only for T₁ cells, comparing T₁ versus T₀-enriched clades. Asterisks indicate cells without RNA information. c, Fold change in gene expression of NF-κB-related genes between the T₁-enriched clade of cells and the remaining T₁ cells identified from the lineage trees in Fig. 4b and Extended Data Fig. 9a.