Extended Data Table 2 Most significant gene-level associations from exome-sequencing analysis

From: Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

  1. The most significant results from gene-level analyses are shown (n = 43,071 unrelated individuals). Genes are ranked according the (two-sided) minimum P value achieved across the four gene-level analyses. Gene, a unique identifier for the gene within our exome-sequencing analysis. Var (CAF), the number of alleles (combined allele frequency (CAF) of variants) in the mask achieving the strongest association across the four tests (that is, the 0/5 1% mask for the weighted test, or the mask with the minimum P value for the minimum P-value test). Burden, results from the (two-sided) burden analysis. SKAT, results from the (two-sided) SKAT analysis. Min P, results from the (two-sided) minimum P-value analysis. Weighted, results from the (two-sided) weighted analysis. OR, the odds ratio as estimated from the burden analysis. P, the (two-sided) P value for the indicated analyses.
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