Fig. 2: Optimizing one step in the total synthesis of maoecrystal V. | Nature

Fig. 2: Optimizing one step in the total synthesis of maoecrystal V.

From: The digitization of organic synthesis

Fig. 2

The natural product is prepared in a longest linear sequence of 11 steps. Step 7 is a reaction of enone 1 and formaldehyde to provide hydroxymethylketone 2. In order to perform this reaction in a laboratory, at least 16 conditions—including workup procedures—are listed above the arrow.

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