Extended Data Fig. 5: Cluster analysis of activated and phagocytosing microglia subtypes. | Nature

Extended Data Fig. 5: Cluster analysis of activated and phagocytosing microglia subtypes.

From: Neuronal vulnerability and multilineage diversity in multiple sclerosis

Extended Data Fig. 5

Hierarchical cluster analysis identifies several homeostatic and activated MS-specific microglia subtypes according to inflammatory lesion stages allowing transcriptomic staging of microglia subtypes. Clusters with enriched genes are marked and annotated a–f (see Supplementary Table 7 for gene list). Note that phagocytosing cells are identified by presence of OL and myelin-associated encoded genes (cluster f at the bottom of the heat map).

Back to article page