Extended Data Fig. 2: Mutational context distribution per tumour type.
From: Pan-cancer whole-genome analyses of metastatic solid tumours
a–e, Variant subtype, mutational context or signature per individual sample for each SNV (a), SNV by COSMIC signature (b), MNV (c), indel (d) or SV (e). Each column chart is ranked within tumour type by mutational load from low to high in that variant class. MNVs are classified by the dinucleotide substitution, with ‘NN’ referring to any dinucleotide combination. SVs are classified by type. DEL, deletion (with microhomology (MH), in repeats and other); DUP, tandem duplication; INV, inversion; TRL, translocation; INS, insertion. Highly characteristic known patterns can be discerned, for example the high rates of C>T SNVs, CC>TT MNVs and COSMIC S18 for skin tumours, and high rates of C>A SNVs and COSMIC S4 for lung tumours.
