Extended Data Fig. 2: The enzymatic activity of caspase-8 is required to inhibit necroptosis.
From: Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
a, Representative images of ileal sections from 10-week-old Casp8WT/flVillincre (n = 4) and Casp8fl/flVillincre (n = 3) mice stained with H&E (top), immunostained for lysozyme (Paneth cells, middle) and PAS (bottom). Scale bars, 100 µm. b, Representative images of ileal sections from 10-week-old Casp8WT/flVillincre (n = 4), Casp8fl/flVillincre (n = 3), Casp8C362S/fl (n = 3) and Casp8C362S/flVillincre (n = 4) mice stained with PAS. Arrows, dead cells. Scale bars, 50 µm.
