Extended Data Fig. 8: Comparison of RORĪ³+Ā Treg cell signature genes of colonic Treg cells from Vdr+/+ and Vdrā/ā mice.
From: Microbial bile acid metabolites modulate gut RORĪ³+Ā regulatory T cell homeostasis
Volcano plots comparing transcriptomes of colonic Treg cells from Vdr+/+Foxp3mRFP and Vdrā/āFoxp3mRFP mice (nĀ =Ā 3). Colonic RORĪ³+Ā Treg cell signature genes are highlighted in red (upregulated) or blue (downregulated). The number of genes from each signature preferentially expressed by one or the other population is shown at the bottom. Data are pooled from two independent experiments. n represents biologically independent animals. To determine the enrichment of certain gene signatures in RNA-seq datasets, a Ļ2 test was used. P < 0.05 was considered statistically significant.
