Extended Data Fig. 8: Graphical representation of the mechanism proposed: local immune response to dietary antigens triggered by bacterial infection leads to food-induced abdominal pain.
From: Local immune response to food antigens drives meal-induced abdominal pain
Bacterial infection (or bacterial toxins, SEB) can trigger break of oral tolerance to food antigens leading to food-induced VHS upon food-antigen re-exposure. OVA-specific IgE antibodies bind to and sensitizes tissue-resident mast cells, which are activated upon re-exposure to OVA during feeding and release mediators that sensitize afferent neurons via H1R-mediated pathway. Components of this figure were created using Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com.
