Extended Data Fig. 1: Case–control germline LOF variant burden analysis.
From: Germline Elongator mutations in Sonic Hedgehog medulloblastoma
a–d, Case–control germline rare LOF variant association analysis in paediatric medulloblastoma subgroups versus paediatric controls (CEFALO) using burden tests (implemented in SKAT). P values were corrected for multiple testing using Bonferroni correction. e–h, Case–control germline rare LOF variant association analysis in paediatric medulloblastoma subgroups versus adult controls (gnomAD) using burden tests (two-sided Fisher’s Exact tests). P values were corrected for multiple testing using Bonferroni correction. i, Case–control germline LOF burden analysis in paediatric medulloblastoma versus adult controls (gnomAD). j–l, Case–control germline LOF burden analysis in infant (j), childhood (k) and adult (l) MBSHH versus adult controls (gnomAD).
