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LifeTime and improving European healthcare through cell-based interceptive medicine

Nature volume 587, pages 377–386 (2020)Cite this article

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A Publisher Correction to this article was published on 17 March 2021

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Abstract

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

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Fig. 1: Early disease detection and interception by understanding and targeting cellular trajectories through time.
Fig. 2: Hallmarks of the LifeTime approach to disease interception and treatment.
Fig. 3: Exploiting the LifeTime dimension to empower disease targeting.
Fig. 4: Blueprint of the LifeTime Initiative.

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Acknowledgements

We acknowledge all participants that have attended and contributed to LifeTime meetings and workshops through many presentations and discussions. We thank J. Richers for artwork and A. Sonsala, A. Tschernycheff and C. Lozach for administrative support. LifeTime has received funding from the European Union’s Horizon 2020 research and innovation framework programme under grant agreement 820431.

Author information

Author notes

  1. These authors contributed equally: Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski

Authors and Affiliations

  1. Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

    Nikolaus Rajewsky, Stanislaw A. Gorski, Grietje Krabbe, Ana Pombo, Christian Popp, Marie Vidal, Jan Philipp Junker, Stefan Kempa & Valentin Popescu

  2. Charité-Universitätsmedizin, Berlin, Germany

    Nikolaus Rajewsky & Norbert Hubner

  3. Berlin Institute of Health (BIH), Berlin, Germany

    Nikolaus Rajewsky, Angelika Eggert, Norbert Hubner & Christof von Kalle

  4. German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

    Nikolaus Rajewsky & Norbert Hubner

  5. Institut Curie, CNRS, PSL Research University, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée Ligue contre le cancer, Paris, France

    Geneviève Almouzni & Inês Pinheiro

  6. VIB Center for Brain and Disease Research, Leuven, Belgium

    Stein Aerts, Bart De Strooper, Bart De Strooper, Elsa Lauwers & Patrik Verstreken

  7. Department of Human Genetics, KU Leuven, Leuven, Belgium

    Stein Aerts & Thierry Voet

  8. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    Ido Amit

  9. Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain

    Michela G. Bertero & Marc A. Marti-Renom

  10. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Christoph Bock

  11. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

    Christoph Bock

  12. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria

    Christoph Bock

  13. Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

    Annelien L. Bredenoord & Karin R. Jongsma

  14. Institute of Human Genetics, UMR 9002, CNRS and University of Montpellier, Montpellier, France

    Giacomo Cavalli

  15. Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy

    Susanna Chiocca, Giuseppe Testa, Nicolo Caporale, Alejandro Lopez Tobon, Luca Marelli & Carlo Emanuele Villa

  16. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands

    Hans Clevers, Alexander van Oudenaarden & Alexander van Oudenaarden

  17. University Medical Center Utrecht, Utrecht, The Netherlands

    Hans Clevers, Alexander van Oudenaarden & Alexander van Oudenaarden

  18. Oncode Institute, Utrecht, The Netherlands

    Hans Clevers, Alexander van Oudenaarden & Alexander van Oudenaarden

  19. The Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

    Hans Clevers

  20. Department of Neurosciences, KU Leuven, Leuven, Belgium

    Bart De Strooper, Bart De Strooper, Elsa Lauwers & Patrik Verstreken

  21. UK Dementia Research Institute at UCL, University College London, London, UK

    Bart De Strooper & Bart De Strooper

  22. Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany

    Angelika Eggert

  23. Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany

    Jan Ellenberg & Stephanie Alexander

  24. Institut Curie, PSL Research University, Paris, France

    Xosé M. Fernández, Dörthe Nickel, Shauna Katz & Alain Puisieux

  25. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

    Marek Figlerowicz, Paulina Jackowiak & Natalia Koralewska

  26. Institute of Computing Science, Poznan University of Technology, Poznan, Poland

    Marek Figlerowicz

  27. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Susan M. Gasser

  28. Faculty of Natural Sciences, University of Basel, Basel, Switzerland

    Susan M. Gasser

  29. Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

    Norbert Hubner & Henrike Maatz

  30. Department of Molecular Biology and Genetics (MBG), Aarhus University, Aarhus, Denmark

    Jørgen Kjems

  31. Interdisciplinary Nanoscience Centre (iNANO), Aarhus University, Aarhus, Denmark

    Jørgen Kjems & Anne F. Nielsen

  32. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria

    Jürgen A. Knoblich

  33. Medical University of Vienna, Vienna, Austria

    Jürgen A. Knoblich

  34. Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Peter Lichter

  35. Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

    Sten Linnarsson

  36. Science for Life Laboratory, Stockholm, Sweden

    Sten Linnarsson

  37. Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium

    Jean-Christophe Marine

  38. Department of Oncology, KU Leuven, Leuven, Belgium

    Jean-Christophe Marine

  39. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK

    John C. Marioni, Helen Parkinson, Oliver Stegle, Catherine Brooksbank & Vera Matser

  40. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK

    John C. Marioni

  41. Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK

    John C. Marioni, Wolf Reik, Oliver Stegle, Thierry Voet, Sarion Bowers & Sarah Teichmann

  42. CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain

    Marc A. Marti-Renom, Ivo Gut & Holger Heyn

  43. Universitat Pompeu Fabra, Barcelona, Spain

    Marc A. Marti-Renom, Ivo Gut & Holger Heyn

  44. ICREA, Barcelona, Spain

    Marc A. Marti-Renom & Alfonso Valencia

  45. Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

    Mihai G. Netea & Andre van der Ven

  46. Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

    Mihai G. Netea & Marien I. de Jonge

  47. Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany

    Mihai G. Netea, Joachim L. Schultze & Matthias Becker

  48. Centre de Biochimie Structurale, CNRS UMR 5048, INSERM U1054, Université de Montpellier, Montpellier, France

    Marcelo Nollmann

  49. VIB Technology Watch, Ghent, Belgium

    Halina R. Novak, Wai Long Tam & Silvie Van den Hoecke

  50. Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy

    Stefano Piccolo

  51. IFOM, The FIRC Institute of Molecular Oncology, Padua, Italy

    Stefano Piccolo

  52. Institute for Biology, Humboldt University of Berlin, Berlin, Germany

    Ana Pombo

  53. Epigenetics Programme, Babraham Institute, Cambridge, UK

    Wolf Reik

  54. Centre for Trophoblast Research, University of Cambridge, Cambridge, UK

    Wolf Reik & Margherita Y. Turco

  55. Department of Translational Research, Institut Curie, PSL Research University, Paris, France

    Sergio Roman-Roman & Céline Vallot

  56. Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany

    Philip Rosenstiel

  57. University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

    Philip Rosenstiel

  58. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Joachim L. Schultze, Matthias Becker, Marc Beyer, Anna Drews, Anja Schneider & Matthis Synofzik

  59. PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany

    Joachim L. Schultze, Matthias Becker, Marc Beyer & Anna Drews

  60. Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Oliver Stegle

  61. Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

    Oliver Stegle, Jan O. Korbel & Kelly Sheehan-Rooney

  62. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

    Amos Tanay

  63. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy

    Giuseppe Testa, Nicolo Caporale, Alejandro Lopez Tobon & Carlo Emanuele Villa

  64. Human Technopole, Milan, Italy

    Giuseppe Testa, Nicolo Caporale, Alejandro Lopez Tobon & Carlo Emanuele Villa

  65. Biomedical Research Foundation, Academy of Athens, Athens, Greece

    Dimitris Thanos & Dimitrios T. Boumpas

  66. Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

    Fabian J. Theis

  67. Department of Mathematics, Technical University of Munich, Munich, Germany

    Fabian J. Theis

  68. Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany

    Maria-Elena Torres-Padilla & Astrid Lunkes

  69. Faculty of Biology, Ludwig-Maximilians Universität, Munich, Germany

    Maria-Elena Torres-Padilla

  70. Barcelona Supercomputing Center (BSC), Barcelona, Spain

    Alfonso Valencia

  71. CNRS UMR3244, Institut Curie, PSL University, Paris, France

    Céline Vallot

  72. Department of Medicine, University of Fribourg, Fribourg, Switzerland

    Lavinia Alberi

  73. Swiss Integrative Center for Human Health SA (SICHH), Fribourg, Switzerland

    Lavinia Alberi

  74. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

    Theodore Alexandrov

  75. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA

    Theodore Alexandrov

  76. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

    Ernest Arenas

  77. Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland

    Claudia Bagni

  78. Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

    Claudia Bagni

  79. Becton Dickinson, San Jose, CA, USA

    Robert Balderas

  80. Science Gallery International, Dublin, Ireland

    Andrea Bandelli

  81. Unit of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

    Burkhard Becher

  82. Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

    Niko Beerenwinkel

  83. Swiss Institute of Bioinformatics, Lausanne, Switzerland

    Niko Beerenwinkel

  84. Institut de Génétique Humaine, Université de Montpellier, Laboratoire de Virologie Moléculaire CNRS-UMR9002, Montpellier, France

    Monsef Benkirame

  85. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK

    Wendy Bickmore

  86. Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

    Erik E. A. L. Biessen

  87. Institute for Molecular Cardiovascular Research, RWTH University Hospital Aachen, Aachen, Germany

    Erik E. A. L. Biessen

  88. ELIXIR Hub, Wellcome Genome Campus, Cambridge, UK

    Niklas Blomberg

  89. Neuropathologisches Institut, Universikätsklinikum, Erlangen, Germany

    Ingmar Blumcke

  90. Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland

    Bernd Bodenmiller

  91. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

    Barbara Borroni

  92. Fourth Department of Internal Medicine, School of Medicine, National & Kapodistrian University of Athens, Athens, Greece

    Dimitrios T. Boumpas & Evangelos J. Giamarellos-Bourboulis

  93. University of Cyprus Medical School, Nicosia, Cyprus

    Dimitrios T. Boumpas

  94. Human Genetics and Cognitive Functions Unit, Institut Pasteur, UMR 3571, CNRS, Université de Paris, Paris, France

    Thomas Bourgeron

  95. Imec, Leuven, Belgium

    Dries Braeken

  96. Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany

    Nils Brose

  97. Department of Child and Adolescent Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands

    Hilgo Bruining

  98. Flanders Institute for Biotechnology (VIB), Ghent, Belgium

    Jo Bury & Geert van Minnebruggen

  99. Department of Medicine & Surgery, Università degli studi di Milano-Bicocca, Milan, Italy

    Giorgio Cattoretti

  100. Centre cantonal autisme, Département de psychiatrie, CHUV, Allières, Lausanne, Switzerland

    Nadia Chabane

  101. Institut National de la Santé et de la Recherche Medicale (INSERM), Paris, France

    Hervé Chneiweiss

  102. Sorbonne Universités, Paris, France

    Hervé Chneiweiss

  103. Centre National de la Recherche Scientifique (CNRS), Paris, France

    Hervé Chneiweiss

  104. National Heart and Lung Institute, Imperial College London, London, UK

    Stuart A. Cook

  105. MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK

    Stuart A. Cook

  106. Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore, Singapore

    Stuart A. Cook

  107. National Heart Research Institute Singapore (NHRIS), National Heart Centre Singapore, Singapore, Singapore

    Stuart A. Cook

  108. Department of System Medicine, University of Rome Tor Vergata, Rome, Italy

    Paolo Curatolo

  109. Department of Laboratory Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

    Marien I. de Jonge

  110. Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

    Bart Deplancke

  111. Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

    Peter de Witte

  112. Institute for Cardiovascular Regeneration, Goethe University, Frankfurt, Germany

    Stefanie Dimmeler

  113. Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

    Bogdan Draganski

  114. Department of Neurology, Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

    Bogdan Draganski

  115. Communication Networks, Content & Technology, European Commission, Brussels, Belgium

    Costica Dumbrava

  116. Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany

    Stefan Engelhardt

  117. Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

    Thomas Gasser & Matthis Synofzik

  118. German Center for Neurodegenerative Diseases, Tübingen, Germany

    Thomas Gasser & Peter Heutink

  119. Hellenic Institute for the Study of Sepsis, Athens, Greece

    Evangelos J. Giamarellos-Bourboulis

  120. Department of NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden

    Caroline Graff

  121. Unit of Hereditary Dementia, Karolinska University Hospital-Solna, Stockholm, Sweden

    Caroline Graff

  122. Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany

    Dominic Grün

  123. Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany

    Dominic Grün

  124. Clinical Memory Research Unit, Lund University, Lund, Sweden

    Oskar Hansson

  125. Memory Clinic, Skåne University Hospital, Malmö, Sweden

    Oskar Hansson

  126. FutureNeuro SFI Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland

    David C. Henshall

  127. Division of Micro- and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden

    Anna Herland

  128. Hertie Institute for Clinical Brain Research, Tübingen, Germany

    Peter Heutink

  129. Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands

    Stephane R. B. Heymans

  130. Department of Cardiovascular Research, University of Leuven, Leuven, Belgium

    Stephane R. B. Heymans

  131. Netherlands Heart Institute (ICIN), Utrecht, The Netherlands

    Stephane R. B. Heymans

  132. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

    Meritxell Huch

  133. Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

    Inge Huitinga

  134. Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

    Inge Huitinga

  135. Montpellier GenomiX (MGX), Institut de Génomique Fonctionnelle, Montpellier, France

    Laurent Journot

  136. Bayer AG Pharmaceuticals, Berlin, Germany

    Jeanne Kehren

  137. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK

    Paulus Kirchhof

  138. Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany

    Paulus Kirchhof

  139. Sandwell and West Birmingham and University Hospitals Birmingham NHS Trusts, Birmingham, UK

    Paulus Kirchhof

  140. German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany

    Paulus Kirchhof

  141. Institute of Neurogenetics, University of Lübeck, Lübeck, Germany

    Christine Klein & Philip Seibler

  142. CARTANA, Stockholm, Sweden

    Malte Kühnemund

  143. Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK

    Angus I. Lamond

  144. Department of Neurology, Hôpital La Pitié Salpêtrière, Paris, France

    Isabelle Le Ber

  145. Neurocenter, Neurosurgery, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

    Ville Leinonen

  146. Unit of Clinical Neuroscience, Neurosurgery, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland

    Ville Leinonen

  147. Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden

    Emma Lundberg

  148. Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

    Matthias Mann

  149. Proteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

    Matthias Mann

  150. Centre for Sociological Research, KU Leuven, Leuven, Belgium

    Luca Marelli

  151. Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

    Luca Marelli & Massimiliano Pagani

  152. Department of Brain Sciences, Imperial College London, London, UK

    Paul M. Matthews

  153. UK Dementia Research Institute at Imperial College London, London, UK

    Paul M. Matthews

  154. Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France

    Fatima Mechta-Grigoriou

  155. MIMETAS, Leiden, The Netherlands

    Radhika Menon & Remko van Vught

  156. IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy

    Massimiliano Pagani

  157. Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

    R. Jeroen Pasterkamp

  158. A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

    Asla Pitkänen

  159. VIB Center for Molecular Neurology, Antwerp, Belgium

    Cyril Pottier, Rosa Rademakers, Kristel Sleegers, Julie van der Zee & Sarah Weckhuysen

  160. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

    Cyril Pottier, Rosa Rademakers, Kristel Sleegers, Julie van der Zee & Sarah Weckhuysen

  161. District Court, Amsterdam, The Netherlands and Court of Appeal, The Hague, The Netherlands

    Dory Reiling

  162. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Orly Reiner

  163. Department of Physics and Astronomy, Bologna University, Bologna, Italy

    Daniel Remondini

  164. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK

    Craig Ritchie

  165. Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK

    Jonathan D. Rohrer

  166. Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany

    Antoine-Emmanuel Saliba & Jörg Vogel

  167. Alzheimer’s Disease and Other Cognitive Disorders Unit, Fundació Clínic per a la Recerca Biomèdica, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

    Raquel Sanchez-Valle

  168. European Center for Law, Science and new Technologies (ECLT), University of Pavia, Pavia, Italy

    Amedeo Santosuosso

  169. Department of Law, University of Pavia, Pavia, Italy

    Amedeo Santosuosso

  170. Institute of Advanced Studies (IUSS), Pavia, Italy

    Amedeo Santosuosso

  171. World Commission on the Ethics of Scientific Knowledge and Technology (COMEST-UNESCO), Paris, France

    Amedeo Santosuosso

  172. Office of Technology Assessment at the German Parliament, Berlin, Germany

    Arnold Sauter

  173. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands

    Richard A. Scheltema

  174. Netherlands Proteomics Center, Utrecht, The Netherlands

    Richard A. Scheltema

  175. Alzheimer Center, Amsterdam University Medical Center, Amsterdam, The Netherlands

    Philip Scheltens

  176. Institute of Lung Biology and Disease, German Center for Lung Research (DZL), Helmholtz Zentrum München, Munich, Germany

    Herbert B. Schiller

  177. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Bonn, Germany

    Anja Schneider

  178. Oncology R&D, Pfizer Inc, San Diego, CA, USA

    David Shields

  179. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands

    August B. Smit

  180. Department of Medicine, University of Cambridge, Cambridge, UK

    Kenneth G. C. Smith

  181. Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK

    Kenneth G. C. Smith

  182. Department of Pharmaceutical Sciences, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium

    Ilse Smolders

  183. Department of Physics, Cavendish Laboratory, Cambridge, UK

    Sarah Teichmann

  184. Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK

    Maria Thom

  185. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK

    Maria Thom

  186. Department of Pathology, University of Cambridge, Cambridge, UK

    Margherita Y. Turco

  187. Department of Cardiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands

    Heleen M. M. van Beusekom

  188. Department of Neurology, University Hospital Leuven, KU Leuven, Leuven, Belgium

    Rik Vandenberghe

  189. Department of Values, Technology and Innovation, Delft University of Technology, Delft, The Netherlands

    Ibo Van de Poel

  190. ViiV Healthcare, London, UK

    Jan van Lunzen

  191. University Medical Center, Hamburg, Germany

    Jan van Lunzen

  192. Department of Neurosciences, University Hospital Leuven, KU Leuven, Leuven, Belgium

    Wim Van Paesschen

  193. Department of Neurology, Erasmus Medical Centre, University Medical Center Rotterdam, Rotterdam, The Netherlands

    John van Swieten

  194. Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Matthijs Verhage

  195. Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam University Medical Center, Amsterdam, The Netherlands

    Matthijs Verhage

  196. Institute of Molecular Infection Biology, University of Würzburg, Würzburg, Germany

    Jörg Vogel

  197. Department of Genetics, Saarland University, Saarbrücken, Germany

    Jörn Walter

  198. Division of Neurology, Antwerp University Hospital, Antwerp, Belgium

    Sarah Weckhuysen

  199. Institute of Pathology, Technical University Munich, Munich, Germany

    Wilko Weichert

  200. Babraham Institute, Babraham Research Campus, Cambridge, UK

    Louisa Wood

  201. Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany

    Anette-Gabriele Ziegler

  202. Technical University Munich, at Klinikum rechts der Isar, Munich, Germany

    Anette-Gabriele Ziegler

  203. Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

    Frauke Zipp

Authors
  1. Nikolaus Rajewsky
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  2. Geneviève Almouzni
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  3. Stanislaw A. Gorski
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  4. Stein Aerts
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  7. Christoph Bock
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  8. Annelien L. Bredenoord
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  10. Susanna Chiocca
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  11. Hans Clevers
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  13. Angelika Eggert
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  14. Jan Ellenberg
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  15. Xosé M. Fernández
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  16. Marek Figlerowicz
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  17. Susan M. Gasser
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  20. Jürgen A. Knoblich
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  22. Peter Lichter
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  23. Sten Linnarsson
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  24. Jean-Christophe Marine
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  26. Marc A. Marti-Renom
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  27. Mihai G. Netea
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  28. Dörthe Nickel
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  29. Marcelo Nollmann
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  30. Halina R. Novak
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  31. Helen Parkinson
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  32. Stefano Piccolo
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  33. Inês Pinheiro
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  34. Ana Pombo
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  35. Christian Popp
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  36. Wolf Reik
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  37. Sergio Roman-Roman
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  50. Thierry Voet
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Consortia

LifeTime Community Working Groups

  • Stein Aerts
  • , Lavinia Alberi
  • , Stephanie Alexander
  • , Theodore Alexandrov
  • , Geneviève Almouzni
  • , Ido Amit
  • , Ernest Arenas
  • , Claudia Bagni
  • , Robert Balderas
  • , Andrea Bandelli
  • , Burkhard Becher
  • , Matthias Becker
  • , Niko Beerenwinkel
  • , Monsef Benkirame
  • , Michela G. Bertero
  • , Marc Beyer
  • , Wendy Bickmore
  • , Erik E. A. L. Biessen
  • , Niklas Blomberg
  • , Ingmar Blumcke
  • , Christoph Bock
  • , Bernd Bodenmiller
  • , Barbara Borroni
  • , Dimitrios T. Boumpas
  • , Thomas Bourgeron
  • , Sarion Bowers
  • , Dries Braeken
  • , Annelien L. Bredenoord
  • , Catherine Brooksbank
  • , Nils Brose
  • , Hilgo Bruining
  • , Jo Bury
  • , Nicolo Caporale
  • , Giorgio Cattoretti
  • , Giacomo Cavalli
  • , Nadia Chabane
  • , Susanna Chiocca
  • , Hervé Chneiweiss
  • , Hans Clevers
  • , Stuart A. Cook
  • , Paolo Curatolo
  • , Marien I. de Jonge
  • , Bart Deplancke
  • , Bart De Strooper
  • , Peter de Witte
  • , Stefanie Dimmeler
  • , Bogdan Draganski
  • , Anna Drews
  • , Costica Dumbrava
  • , Angelika Eggert
  • , Jan Ellenberg
  • , Stefan Engelhardt
  • , Xosé M. Fernández
  • , Marek Figlerowicz
  • , Susan M. Gasser
  • , Thomas Gasser
  • , Evangelos J. Giamarellos-Bourboulis
  • , Stanislaw A. Gorski
  • , Caroline Graff
  • , Dominic Grün
  • , Ivo Gut
  • , Oskar Hansson
  • , David C. Henshall
  • , Anna Herland
  • , Peter Heutink
  • , Stephane R. B. Heymans
  • , Holger Heyn
  • , Norbert Hubner
  • , Meritxell Huch
  • , Inge Huitinga
  • , Paulina Jackowiak
  • , Karin R. Jongsma
  • , Laurent Journot
  • , Jan Philipp Junker
  • , Shauna Katz
  • , Jeanne Kehren
  • , Stefan Kempa
  • , Paulus Kirchhof
  • , Jørgen Kjems
  • , Christine Klein
  • , Jürgen A. Knoblich
  • , Natalia Koralewska
  • , Jan O. Korbel
  • , Grietje Krabbe
  • , Malte Kühnemund
  • , Angus I. Lamond
  • , Elsa Lauwers
  • , Isabelle Le Ber
  • , Ville Leinonen
  • , Peter Lichter
  • , Sten Linnarsson
  • , Alejandro Lopez Tobon
  • , Emma Lundberg
  • , Astrid Lunkes
  • , Henrike Maatz
  • , Matthias Mann
  • , Luca Marelli
  • , Jean-Christophe Marine
  • , John C. Marioni
  • , Marc A. Marti-Renom
  • , Vera Matser
  • , Paul M. Matthews
  • , Fatima Mechta-Grigoriou
  • , Radhika Menon
  • , Mihai G. Netea
  • , Dörthe Nickel
  • , Anne F. Nielsen
  • , Marcelo Nollmann
  • , Halina R. Novak
  • , Massimiliano Pagani
  • , Helen Parkinson
  • , R. Jeroen Pasterkamp
  • , Stefano Piccolo
  • , Inês Pinheiro
  • , Asla Pitkänen
  • , Ana Pombo
  • , Valentin Popescu
  • , Christian Popp
  • , Cyril Pottier
  • , Alain Puisieux
  • , Rosa Rademakers
  • , Nikolaus Rajewsky
  • , Wolf Reik
  • , Dory Reiling
  • , Orly Reiner
  • , Daniel Remondini
  • , Craig Ritchie
  • , Jonathan D. Rohrer
  • , Sergio Roman-Roman
  • , Philip Rosenstiel
  • , Antoine-Emmanuel Saliba
  • , Raquel Sanchez-Valle
  • , Amedeo Santosuosso
  • , Arnold Sauter
  • , Richard A. Scheltema
  • , Philip Scheltens
  • , Herbert B. Schiller
  • , Anja Schneider
  • , Joachim L. Schultze
  • , Philip Seibler
  • , Kelly Sheehan-Rooney
  • , David Shields
  • , Kristel Sleegers
  • , August B. Smit
  • , Kenneth G. C. Smith
  • , Ilse Smolders
  • , Oliver Stegle
  • , Matthis Synofzik
  • , Wai Long Tam
  • , Amos Tanay
  • , Sarah Teichmann
  • , Giuseppe Testa
  • , Dimitris Thanos
  • , Fabian J. Theis
  • , Maria Thom
  • , Maria-Elena Torres-Padilla
  • , Margherita Y. Turco
  • , Alfonso Valencia
  • , Céline Vallot
  • , Heleen M. M. van Beusekom
  • , Rik Vandenberghe
  • , Silvie Van den Hoecke
  • , Ibo Van de Poel
  • , Andre van der Ven
  • , Julie van der Zee
  • , Jan van Lunzen
  • , Geert van Minnebruggen
  • , Alexander van Oudenaarden
  • , Wim Van Paesschen
  • , John van Swieten
  • , Remko van Vught
  • , Matthijs Verhage
  • , Patrik Verstreken
  • , Marie Vidal
  • , Carlo Emanuele Villa
  • , Thierry Voet
  • , Jörg Vogel
  • , Christof von Kalle
  • , Jörn Walter
  • , Sarah Weckhuysen
  • , Wilko Weichert
  • , Louisa Wood
  • , Anette-Gabriele Ziegler
  •  & Frauke Zipp

Contributions

All authors contributed to the writing of the article and provided comments and feedback. They all approved submission of the article for publication. The individuals listed at the end of the paper are members of Working Groups that contributed to the writing of the LifeTime Strategic Research Agenda (listed in full in the Supplementary Information). Please note that the complete LifeTime Community is much broader and includes many associates and supporters that are actively contributing to and advocating for LifeTime (further information can be found at https://lifetime-initiative.eu).

Corresponding authors

Correspondence to Nikolaus Rajewsky, Geneviève Almouzni or Stanislaw A. Gorski.

Ethics declarations

Competing interests

C.B. is an inventor on several patent applications in genome technology and cofounder of Aelian Biotechnology, a single-cell CRISPR screening company. H.C. is a non-executive board member of Roche Holding, Basel. A.P. holds European and US patents on ‘Genome Architecture Mapping’ (EP 3230465 B1, US 10526639 B2). W.R. is a consultant and shareholder of Cambridge Epigenetix. T.V. is co-inventor on licensed patents WO/2011/157846 (methods for haplotyping single cells), WO/2014/053664 (high-throughput genotyping by sequencing low amounts of genetic material), WO/2015/028576 (haplotyping and copy number typing using polymorphic variant allelic frequencies). All other authors declare no competing interests.

Additional information

Peer review information Nature thanks Michael Snyder, Ali Torkamani and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Supplementary Information

Author and affiliation list for members of the LifeTime Working Groups.

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Rajewsky, N., Almouzni, G., Gorski, S.A. et al. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 587, 377–386 (2020). https://doi.org/10.1038/s41586-020-2715-9

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