Extended Data Fig. 10: Synthesis of a 4sT-phosphoramidite building block. | Nature

Extended Data Fig. 10: Synthesis of a 4sT-phosphoramidite building block.

From: Conformation of sister chromatids in the replicated human genome

Extended Data Fig. 10

a, Synthesis of 5′-O-(4,4′-Dimethoxytrityl)-S-(2-cyanoethyl)-4-thiothymidine 3′-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. b, 1H-NMR (700 MHz, CDCl3) of 4sT phosphoramidite (diastereomeric mixture). c, 31P-NMR (282 MHz, CDCl3) of 4sT phosphoramidite (diastereomeric mixture).

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