Fig. 4: Cardiac immune populations and cell–cell interactions.

a, Manifold of 40,868 myeloid and lymphoid cardiac cells. NP, neutrophils; NK, natural killer; NKT, natural killer T cells; CD4+T_tem, effector-memory CD4⁺ T cells; CD4+T_cytox, CD4⁺ cytotoxic T cells; CD8+T_tem, CD8⁺ effector-memory T cells; CD8+T_cytox, CD8⁺ cytotoxic T cells; DC, dendritic cells; CD14+Mo, CD14⁺ monocytes; CD16+Mo, CD16⁺ monocytes; Mo_pi, pro-inflammatory monocytes; IL17RA+Mo, IL17RA⁺ monocytes; MP_AgP, HLA class II antigen-presenting macrophages; MP_mod, monocyte-derived macrophages; LYVE1+MP1–3, M2-like, LYVE1⁺ macrophages sets 1–3; DOCK4+MΦ1–2, DOCK4⁺ macrophage sets 1–2; B_cells, B cells; plasma, plasma B cells. b, BioRender infographic summarizes predicted cell–cell interaction circuits between atrial and ventricular cardiomyocytes, FB4 and immune cells involved in tissue repair in the heart and SKM. Data are available in Supplementary Table 17. c, Gene expression signature for cardiac-specific LYVE1⁺ macrophages compared against predicted matched populations in skeletal muscle and kidney.