Extended Data Fig. 6: DNA methylation level and distribution in adult tissues.
From: A map of cis-regulatory elements and 3D genome structures in zebrafish
a, Fraction of total CpGs with low (<25%), medium (≥25% and <75%), and high (≥75%) methylation levels and mean CpG methylation levels (mCG/CG) in zebrafish adult tissues (the mCG/CG ratio, from left to right, 0.788, 0.859, 0.790, 0.777, 0.791, 0.797, 0.781, 0.777, 0.804, 0.789, 0.781). b, Distribution of CpG methylation levels across zebrafish adult tissues. c, The distribution of non CpG methylation in 11 adult tissues. d, Mean methylation levels of the tissue-specific gene promoters. n represents the number of tissue-specific gene promoter. e, Mean methylation level of CpGs overlapping different genomic features or repetitive element classes. CDS, coding sequence. f, Number of UMRs and LMRs in zebrafish tissues and their overlap with enhancer and promoters (left panel) (number of UMR and LMR, from top to bottom, 14,990, 10,569, 14,569, 14,587, 14,831, 14,289, 13,842, 13,569, 14,424, 14,374, 13,908, 30,009, 7,916, 19,038, 21,411, 22,591, 16,796, 14,961, 16,268, 17,481, 15,932, 15,665) and ATAC-seq peaks (right panel)(numbers of UMR and LMR are the same with left panel). g, Clustering of tissue-specific hypoDMRs. Values in the heat map are mean methylation levels of hypoDMRs (n = 17,654, number of tissue-specific hypoDMRs).
