Extended Data Fig. 2: Cellular processes targeted in this study and changes in thermal stability reflect protein complex architecture in E. coli mutants.

a, Distribution of cellular processes targeted in this study compared to the general distribution of the E. coli genome using Clusters of Orthologous Groups (COG). b, c, Schematic representation of protein complexes targeted by genetic perturbations in this study. Protein missing (encoded by gene deleted) is highlighted by a dashed line and other complex members are coloured according to their thermal stability (b) or abundance (c) in that mutant. *|z-score| >1.96 and with q-value ≤ 0.05. ΔtolC data are from ref. ²⁰.