Extended Data Fig. 3: Protein co-expression patterns provide insight into gene expression regulation. | Nature

Extended Data Fig. 3: Protein co-expression patterns provide insight into gene expression regulation.

From: The functional proteome landscape of Escherichia coli

Extended Data Fig. 3

a, Correlation of DegP and OmpF log2-transformed fold changes to control in each of the genetic perturbations probed here (n = 120, as OmpF is not detected in ΔompF) at each temperature (colour coded; n = 10). Mutants that lead to cell envelope stress (highlighted), and therefore activation of stress response (see also b) lead to upregulation of DegP and downregulation of OmpF. b, Schematic representation of regulation of degP and ompF genes. CpxAR two-component system regulates both genes, while EnvZ/OmpR regulates only ompF. Heatmap shows Spearman’s rank correlation (calculated as in Fig. 3a) for proteins involved in regulation of degP and ompF.

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