Extended Data Fig. 9: Protection from lethal YF17D.
From: A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
a, Ifnar−/− mice were vaccinated with either a single 400 PFU intraperitoneal (i.p.) dose of YF17D (black) (n = 7) or YF-S0 (green) (n = 10), or sham (grey, n = 9). After 21 days, mice were challenged by intracranial (i.c.) inoculation with a uniformly lethal dose of 3 × 103 PFU of YF17D and monitored for weight evolution (b) and survival (c). The number of surviving mice at study end point (day 15) is indicated. Data are from two independent experiments.
