Fig. 4: Single-shot vaccination in hamsters.
From: A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
Three groups of hamsters were vaccinated once intraperitoneally with sham (white) or YF-S0 at two different doses; 103 PFU (low) (green circles) and 104 PFU (high) (green triangles) of YF-S0 at 21 days before challenge. A fourth group was vaccinated with the high 104 PFU dose of YF-S0 at 10 days before challenge (green squares). Data are from n = 8 hamsters per group from a single experiment a, b, NAbs (a) and binding antibodies (n = 3; sera from 2 or 3 hamsters were pooled) (b) before challenge. c, d, Viral loads in lungs four days after infection, quantified by RT–qPCR (c) and virus titration (d). e, Spider web plot showing histopathological score for lung damage normalized to sham treatment (white circles). Data are median ± IQR. Two-tailed uncorrected Kruskal–Wallis test was applied.
