Extended Data Fig. 9: Binding of human ACE2 to the RBDs of the wild-type SARS-CoV-2 spike, spike(N501Y) and spike(N501Y, E484K, K417N) proteins.
From: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

a–c, Biolayer interferometry binding analysis of the human ACE2 (huACE2) ectodomain (residues 1–615) to immobilized RBD of wild-type SARS-CoV-2 (a) and the RBD of B.1.1.7 spike(N501Y) (b) and spike (N501Y, E484K, K417N) proteins (c). Black lines correspond to a global fit of the data using a 1:1 binding model.