Extended Data Fig. 6: Notum drives the elimination of WT cells from the crypt independent of apoptosis.
From: NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
a, Quantification and representative confocal imaging of cleaved caspase-3+ cells (CC3) within clonal crypts and the surrounding non-mutant epithelium in NotumWT and NotumcKO mice at 14 d.p.i. n = 4 per genotype. Crypts adjacent (Adj.) to or remote (Rem.) from Apc-mutant (clone) crypts were scored as non-mutant epithelia. The red arrows indicate CC3+ cells (green) in areas of Apc-mutant clones (purple border) and surrounding epithelia. Scale bar, 50 μm. Data are mean ± s.e.m.; Mann–Whitney two-tailed U-test.
