Extended Data Fig. 8: Landscape of driver mutations.

a, Mutational landscape of the 32 putative driver genes across different organs from the 5 donors. b, The functional interaction (network of the 32 driver genes. Driver genes are in blue nodes and linker genes (those not significantly mutated but highly connected to driver genes in the network) are in pink nodes. c, Significantly enriched pathways of the 32 driver genes. The vertical red line marks a false discovery rate (FDR) of 0.01. d, Bar plot showing the numbers of total mutations and cancer hotspot mutations in driver genes. The percentages of hotspot mutations are labelled on the top of the bar plot. e, Fraction of driver mutations that are private or shared by more than one biopsy sample. f, Heat maps showing the ratio of the numbers of observed to expected (O/E) driver mutations across different organs (left) and the P values for the enrichment (right). P values from one-sided hypergeometric tests. g, Bar plots comparing the number of mutations in gastric cancer top-10 most frequently mutated driver genes in TCGA with normal stomach and cardia samples in this study. Adjustment for multiple comparisons was performed. Adjusted P values (q-value) are labelled.