Extended Data Fig. 14: mtDNA mutation burden and spectrum.
From: Somatic mutation rates scale with lifespan across mammals
a, Total somatic mtDNA mutations called (substitutions and indels; top), somatic mutation burden per mtDNA copy (middle), and estimated mtDNA copy number in each crypt sample. Samples are arranged horizontally as in Fig. 1b, with samples from the same individual coloured in the same shade of grey. b, Mutational spectra of mtDNA substitutions in each species. The x axis shows 96 mutation types on a trinucleotide context, coloured by base substitution type; the y axis shows mutation counts. Mutations on the upper and lower halves of the spectrum represent substitutions with the pyrimidine base located on the heavy and light strands of mtDNA, respectively.
