Extended Data Fig. 9: Schematic of a working model of astrocyte reactivity transcriptional regulation.
From: Divergent transcriptional regulation of astrocyte reactivity across disorders
Divergent non-cell autonomous, disorder-selective reactivity triggers lead to context-dependent and combinatorial TR interactions in which a core set of TRs (TRA & TRB) is active across many if not most forms of astrocyte reactivity. These core TRs can nevertheless regulate different cohorts of DEGs in different disorders and contexts via complex and interdependent combinatorial interactions that also involve disorder- or context-selective TRs (TRC - TRn). These TR interactions can be influenced by astrocyte cell autonomous factors such as mutations, polymorphisms, or by differing basal starting conditions that can vary with regional or local astrocyte heterogeneity or with other factors such as exposure to previous insults. These TR interactions give rise to the exquisitely heterogenous DEG profiles associated with different astrocyte reactivity states in different disorders and different contexts.
