Extended Data Fig. 3: Glucose intolerance phenotype does not persist to F2 generation.
From: Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency
a, Schematic diagram of the breeding for F2 offspring. Circles designate females and squares designate males. F2 were generated by intercrossing F1 males and females from control and pregestational hyperglycemic mothers. b, GTT results of male (left) and female (right) offspring at 24 weeks of age. c, Area under the curve (AUC) of the blood glucose levels in male and female. b–c, Ctrl♂×Ctrl♀, Ctrl♂×HG♀, HG♂×Ctrl♀, HG♂×HG♀: n = 8 mice per group for both males and females. Data are presented as the mean ± s.e.m.; two-tailed P values were calculated by one-way repeated-measurements ANOVA (b) or one-way ANOVA (c). Statistical details are in Supplementary Table 5.
