Extended Data Fig. 7: Transcriptome-wide association study of stroke in multiple tissues.
From: Stroke genetics informs drug discovery and risk prediction across ancestries
Heatmap of the transcriptome-wide association studies (TWAS) of stroke (any stroke and stroke subtypes) showing transcriptome-wide significant associations with supporting evidence from colocalization; Coloured squares are TWAS significant associations based on two-sided p-values after multiple testing correction (p < 2.0 × 10−6); * Conditionally significant (p < 0.05) and COLOC PP4 ≥ 0.75; Genes are presented on the x-axis, those underlined in blue are in a stroke GWAS locus, those underlined in purple are not within a genome-wide significant stroke risk locus (Methods); Tissue types are on the y-axis (blue: cross-tissue weights; pink: arterial; orange: heart; green: brain).
