Fig. 3: Genomics-driven drug discovery.
From: Stroke genetics informs drug discovery and risk prediction across ancestries
Overlap enrichment analysis using GREP22 (top). Middle, integrating MR results using cis- and trans-pQTLs as instrumental variables with data from drug databases. Bottom, negative correlation tests between compound-regulated gene expression profiles and genetically determined case–control gene expression profiles using Trans-Phar.
