Extended Data Fig. 4: Results from a phenome-wide association analysis.
From: Common and rare variant associations with clonal haematopoiesis phenotypes
Results from a phenome-wide association analysis are shown for the thirty SNPs from our GWAS that had the largest number of significant associations (P < 5 x 10−8). Associations are most common among hematological, body mass, and auto-immune traits (seen across the ‘dermatology’, ‘gastroenterology’, and ‘other’ phenotypic categories). For visualization, associations with –log10(P) < 50 were set to 50. Association models were run with age, age2, sex, and age-by-sex, and 10 ancestry-informative principal components (PCs) as covariates. P-values are uncorrected and derive from two-sided tests performed using approximate Firth logistic regression. See Table S10 for full associations results.
