Extended Data Fig. 4: Intra-patient heterogeneity of HGSOC tumour microenvironments.

a, Cell type composition based on scRNA-seq for CD45⁻ samples (left) and CD45⁺ samples (right). Dot plot of sample ranks grouped by patient. Coloured arrows indicate enrichment (red) or depletion (blue) of ovarian cancer cells (left) and T cells (right) in non-adnexal over adnexal samples. b, Cell type composition based on H&E with lymphocyte ranks in tumour-rich (left) and stroma-rich (right) compartments. Panels analogous to a. c, Cell type composition based on mpIF with CD8⁺ T cell ranks in tumour-rich (left) and stroma-rich (right) compartments. Panels analogous to a.