Fig. 6: Spatial topologies of in situ cellular interactions.
From: Ovarian cancer mutational processes drive site-specific immune evasion
a, Representative mpIF fields of view (FOVs) highlighting common features of the TME and showing one adnexal sample per mutational signature. First column, raw pseudocolour images; second column, cellular phenotypes of segmented cells; third and fourth columns, proximity of phenotype pairs, highlighting PD-L1–PD-1 interactions with colour-coded phenotypes and edges depicting nearest-neighbour distances. Only edges joining pairs of cells within 250 μm of each other are shown. b, Nearest-neighbour distance from CD8+ T cell phenotypes to panCK+PD-L1+ cancer cells aggregated across FOVs, with samples grouped by anatomical site and mutational signature. Vertical lines indicate the median nearest-neighbour distance.
