Extended Data Fig. 1: Experimental workflow.
From: Glioblastoma remodelling of human neural circuits decreases survival
a, Schematic of study workflow. In human participants with dominant hemisphere gliomas, we applied subcortical high density electrocorticography during audiovisual speech initiation to assess tumour intrinsic neuronal circuit dynamics. Focusing on glioblastoma, we then assessed long-range functional connectivity using magnetoencephalography (MEG) imaginary coherence. b, Extra-operative language assessments were performed for correlation with biological assays. c, Long-range measure of tumour intrinsic functional connectivity identified regions of high and low connectivity for site specific biopsies which were used for in vivo and in vitro cell biology experiments. d, Multiple layered approach including clinical variables, cognition assessments, human and animal model network dynamics, and cell biology experiments serves as a platform for glioma influence on neural circuit dynamics.
