Extended Data Fig. 3: Speech initiation neural activity in lateral prefrontal cortex (LPFC).
From: Glioblastoma remodelling of human neural circuits decreases survival
a, Spectral data of time vs frequency from 100–150 Hz for all tumour and non-tumour electrodes show the expected pattern of HgP increasing above 50 Hz. b, High gamma power (HGp) recording from single electrodes overlying tumour-infiltrated regions of brain. Dark line and shaded region represent mean and 95% confidence interval, respectively. c, Reconstructed time series of HGp from non-tumour electrodes demonstrating expected spatial and temporal pattern of neural activity within lateral prefrontal cortex. d, e, Electrodes matched to anatomical areas across tumour and non-tumour demonstrate hyperexcitability with glioma-infiltrated cortex. Plots are centred on median, with dark bars indicating the first and third quartiles, and whiskers the minimum and maximum points (n = 101 per group, P = 0.0163). P value determined by two-sided linear mixed-effects model with corrections for multiple comparisons made using the FDR method (b) and two-tailed Student’s t-test (e). *P < 0.05.
