Extended Data Fig. 3: Estimation of constraint for aggregated regulatory annotations.
From: A genomic mutational constraint map using variation in 76,156 human genomes
a,b, Gnocchi scores of aggregated promoter (dark purple), enhancer (light purple), microRNA (miRNA; dark blue), and long non-coding RNA (lncRNA; light blue) annotations are compared against those of exonic (a) and non-coding (b) regions at a 1kb scale. The Gnocchi score percentiles of each annotation (y-axis) are benchmarked by the score deciles of exonic or non-coding regions (10–100 percentiles; x-axis); the grey dashed vertical line indicates the median (50th percentile).
